In short words, unless it is placed where viewers are not supposed to get near it, too big prints has an invasive and visual abusive quality which annoys me. On the other hand I am in love with small prints, specially contact prints which I enjoy making. Not only from small large format negatives but also from meddle format. Even 6x4.5 middle format, they look charming and elegant with the appropriate matt and frame to hold it nicely with our hands and stand prominent for our eyes.
Small prints will appeal to you for its true qualities and not for throwing it on your face or making things impressive just by turning them unfamiliar too big.